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The FDA-approved labeling for GLP-1 medications lists gastrointestinal symptoms as the most frequent adverse reactions, but comprehensive tracking should capture the full spectrum of potential effects

For instance, the benefits of agents targeting metabolic pathways may be enhanced by adding drugs with anti-inflammatory and anti-fibrotic effects

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Clinical trial data including the FLOW trial (NEJM, 2024) and earlier cardiovascular outcome trials such as LEADER and SUSTAIN-6 suggest these agents may offer renoprotective benefits in people with type 2 diabetes and CKD , including reductions in albuminuria and slowing of disease progression

Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis