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Leaving vials in direct light or heat A sunny counter or a car interior can push a vial well past safe storage temperatures within hours

By contrast, high irradiance overexcites the photosystems particularly photosystem II (PSII) overloading the electron transport chain and driving excessive production of reactive oxygen species (ROS) (Pospil 2016

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However, melanoma of the lip, although rare, can sometimes look similar to a melanotic macule in its early stages, which is why dermatologists recommend that any new pigmented lesion on the lip, or any existing one that changes in size, color, or shape, should be evaluated to rule out a more serious diagnosis