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"Reduced" simply means it is in its active, non-oxidized state, ready to work
Lee, Steffen, and Jacobs at the University of Minnesota analyzed dietary patterns in 3,146 young adults in the CARDIA study, published in the American Journal of Clinical Nutrition in 2004
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Furthermore, FMO3 has been shown to serve as a central regulator of tissue cholesterol balance and to be involved in insulin resistance and dyslipidemic changes in mouse models, suggesting the FMO3 and TMAO pathway as potential mediators of diabetes associated atherosclerosis 52,53
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