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Since the discovery of FSP1, more and more GPX4-independent ferroptosis pathways have been discovered in various physiological and pathological processes Drugs targeting GPX4-independent ferroptosis pathway may become a new direction for the treatment of diseases

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Again, in the first study using FOXO4-DRI to induce apoptosis in senescent cells, the senescent cells were generated by irradiation or doxorubicin ( As shown in Figure 3, FOXO4-DRI pre-treatment is the dedifferentiation of chondrocytes during the in vitro expansion