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BMI is important, but healthcare providers evaluate the whole patient
It is also enough of a guardrail that the protocol produces the response we are paying for
Sulofenur [( N -(5-indanesulfonyl)- N -(4-chlorophenyl)urea, LY18664], the prototypic member of this class ( Figure 2C ), was evaluated in clinical trials on a variety of patients with kidney (Mahjoubi et al., 1993), ovary (OBrien et al., 1992), breast (Talbot et al., 1993), lung (Munshi et al., 1993), and stomach (Kamthan et al., 1992) cancers
The result is an unbalanced autonomic response: the "accelerator" keeps firing, but the "brake" does not engage (Cutsforth-Gregory & Sandroni, Handbook of Clinical Neurology , 2019