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We are thankful for the technical services provided by the Transgenic Mouse Models Core Facility of the National Core Facility for Biopharmaceuticals, National Science and Technology Council, Taiwan, as well as the Gene Knockout Mouse Core Laboratory of the National Taiwan University Center of Genomic and Precision Medicine

The Vermeulen study found that ALCAR specifically and significantly improved mental fatigue and cognitive concentration (p = 0.015), validating its ability to cross the blood-brain barrier and support neurological function

Next step: Endocrine workup including morning cortisol and ACTH levels

Those with active illness, uncontrolled asthma, or serious kidney or liver disease need close supervision

doi: 10.1104/pp.114.4.1443 17 Gall.BelaK.HajmalA.FaragN.HorvthE.HorvthM.et al