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The final stages of spinal stenosis involve severe spinal canal narrowing (75% and above) and advanced nerve compression, causing symptoms like debilitating lower back and leg pain, numbness in the lower extremities and saddle region, an inability to stand or walk, and loss of bladder or bowel control
Findings vary depending on study design, model type, and experimental parameters
Differential pathophysiological mechanisms between CHS and EHS While CHS and EHS share core pathogenic pathways (e.g., hyperthermia, inflammation, cell death), their mechanistic features differ significantly due to distinct patient demographics and triggers: Inflammatory kinetics EHS (predominant in young, active individuals) is characterized by rapid, exertion-amplified inflammatory responses
The net result is angiogenesis new blood vessels forming at injury sites, bringing oxygen and nutrients right where they're needed
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