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For any synthetic AT developed, it is important to know which biomolecule the agent is designed to protect, by which mechanism (scavenging RS, preventing RS formation, increasing endogenous defense mechanisms, and/or supporting oxidative damage repair), whether it can generate RS, and if there are any adverse effects associated with RS suppression

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In addition, these cells do not express a significant number of leukocyte adhesion molecules (LAMs) as other tissues, thereby reducing the number of immune cells that can overcome the barrier to penetrate into the cerebral region (S-Pereira et al., 2012

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