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Tirzepatide (a once-weekly injection) led to an average weight reduction of about 16% after 12 to 18 months

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By contrast, insulin has been shown to decrease expression of muscle LPL

Major adverse cardiovascular events (MACE)including cardiovascular death, non-fatal myocardial infarction, and non-fatal strokewere not increased with Zepbound treatment, though the trial was not specifically powered to evaluate cardiovascular outcomes