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GRK2 phosphorylates the active form of GPCRs, thus prompting the recruitment of -arrestins and the uncoupling of G proteins

doi: 10.1016/j.cell.2022.06.050 39 HoCLTanHQChuaKJKangALimKHLingKLet al

Clin Neurophysiol 127(7):26702681 Bersano E, Sarnelli MF, Solara V, Iazzolino B, Peotta L, De Marchi F, Facchin A, Moglia C, Canosa A, Calvo A, Chi A, Mazzini L (2020 Aug) Decline of cognitive and behavioral functions in amyotrophic lateral sclerosis: a longitudinal study

Trial data showed that participants who remained compliant through plateau periods eventually achieved similar weight loss to those who experienced steady linear loss