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Increasing the dose of phenobarbitone in the rat will correlate with liver enlargement and enzyme induction only up to a point, after which there is no further increased liver enlargement and hepatotoxicity observed (Crampton et al

Hamster liver contains significant levels of AFB 1 -GSH-conjugating activity but the GST involved have not been characterized

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GHK-Cu has the strongest mechanistic literature of the four