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Redox regulation by reversible protein S-thiolation in bacteria

Based on studies with R- and S-7-hydroxywarfarin, we predicted that all hydroxywarfarin reductions are enantioselective toward R substrates and enantiospecific for S alcohol metabolites

Rationale for metabolic state-driven as an approach for restoring susceptibility in multidrug-resistant pathogens Recent findings demonstrate that the local environment modulates bacterial drug uptake and other aspects of bacterial metabolism 10,11,16,17,18

Summary ZMA is relatively safe at standard doses, but it may cause side effects at very high doses