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In pre-specified analyses for time to first occurrence of MACE, there were 44 MACE-5 (all-cause death, heart attack, stroke, heart failure event, or coronary revascularization) events observed in participants randomized to retatrutide (pooled 9mg and 12mg) and 52 events observed in those randomized to placebo, resulting in a hazard ratio of 0.82

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