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(1996, Journal of Endocrinology) reported IGF-1 LR3 was 1.5-2x more potent than equimolar native IGF-1 for body weight gain, organ growth, and anti-catabolic effects when continuously infused in normal and dexamethasone-treated rats

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15, 16 The compensatory immune mechanisms then act to protect against the development of colitis, even when there is increased gut permeability