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Animals were subject to a timed-mating protocol, whereby prior exposure of females to dirty bedding from males allowed for stimulation and synchronization of the females estrous cycles through the Whitten Effect (Jemiolo et al, 1986)

25 The Salt Strategy: Novo Nordisk targeted entities using semaglutide sodium or semaglutide acetatesalt forms of the molecule distinct from the FDA-approved base form

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Also, in patients who have an eGFR 60 mL/min/1.73 m 2 and who tolerate 100 mg once daily, the canagliflozin dose can be increased to 300 mg once daily if additional glycemic control is needed [45]