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Chronic inflammation is associated with many health problems

These mechanisms can lead to placental thrombosis and ultimately result in miscarriage

Thompson WD, Walter SD (1988) Kappa and the concept of independent errors

At the highest level of evidence, a Cochrane systematic review and meta-analysis incorporating 16 RCTs (n = 827) confirmed that oral BCAA supplementation significantly reduced the risk of hepatic encephalopathy (risk ratio 0.73, 95% CI 0.610.88

However, real-world experience and the pharmacokinetic principles of volume of distribution suggest that lighter individuals benefit from a more conservative start, while heavier individuals may tolerate a slightly more aggressive approach