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Overproduction and reduced clearance of A are the key drivers of the disease, and A toxicity and neurodegeneration are mediated through tau (1)

Biochem Pharmacol 38(8):12471255 Duthie SJ, Melvin WT, Burke MD (1994) Bromobenzene detoxification in the human liver-derived HepG2 cell line

In this paradigm, some of the abnormally methylated targets disappeared in the postnatal stage, whereas others emerged at the prepubertal stage

Gastrointestinal side effects were common, so gradual dose escalation, proactive management of nausea and constipation, and careful monitoring during treatment initiation seem particularly sensible