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Interestingly, PA treatment increases CD36 protein expression in SUM-159 but not in MCF-7 cells

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Neuron-mediated regulation of CBF Neurons release chemical signals that directly or indirectly influence receptors on pericytes and astrocytes, resulting in either decreased CBF due to depolarization and cell contraction or increased CBF through hyperpolarization and cell relaxation

The practical implication is that occasional dosing interruptionswhether planned or accidentalshouldn't significantly impact research outcomes in protocols focused on long-term neuroplasticity rather than acute cognitive performance