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Since the discovery of insulin in 1921, several attempts to develop oral insulin formulations have failed, demonstrating the difficulty as well as the challenge of developing oral peptides and proteins

But it took roughly 60 times the subcutaneous dose to get equivalent blood sugar effects, and the cost of that much insulin made the product commercially impractical

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Therefore, FOXO4-DRI shows potential as a keloid treatment to prevent the aggressiveness and relapse of keloids by alleviating the inflammatory microenvironment

Nov 2009;15(11):RA256-62