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There is increasing evidence of the benefits of growth hormone treatment in adults with PWS, such as a continued increase in lean mass and decrease in fat mass, improved muscle strength, improved mental and cognitive function and possibly improved quality of life ( The role of metabolic surgery is well-established in non-syndromic obesity, but its efficacy in PWS is controversial ( Our case series has several limitations

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When faced with this issue, adding more oestrogen often isnt the solution