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At the end of 2025, there were 5,396 total reports regarding Wegovy, including 35 deaths and 1,825 reports of gastrointestinal side effects

Advise patients using oral hormonal contraceptives to switch to a non-oral contraceptive method, or add a barrier method of contraception, for 4 weeks after initiation with ZEPBOUND and for 4 weeks after each dose escalation

According to American College of Gastroenterology guidelines, an 8-week trial of daily PPI therapy is appropriate for typical GERD symptoms, with potential step-down therapy thereafter

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