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They are usually transient and seldom require discontinuance of therapy

A prospective pilot study run in 2004 involved 18 non-diabetic patients with biopsy-proven NASH and tested hepatic histological improvement as the primary outcome after a 48-week course of pioglitazone: the results showed significant improvement in histology regarding all major features of NASH (steatosis, parenchymal inflammation, cellular injury, and Mallory bodies) including fibrosis, despite a significant increase in body weight [59]

Human clinical trials The effects of glutamine on hormone secretion and pyloric motility seem to conform in a dose-dependent manner [36]

Overall, dapagliflozin is unlikely to affect the pharmacokinetics of concurrently administered medications that are P-gp, OCT2, OAT1, or OAT3 substrates

10.1016/j.intimp.2023.110593 115 MarkoulliM.AhmadS.ArcotJ.AritaR.Benitez-Del-CastilloJ.CafferyB.et al (2023)