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Peptidase enzymes saturate at high concentrations, temporarily slowing degradation rates and extending plasma half-life from 30 minutes to 4560 minutes at doses above 5mg

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doi: 10.1007/S00125-013-3043-5 48 KrogvoldLEdwinBBuanesTFriskGSkogOAnagandulaMet al

4.1 Evidence from epidemiological and clinical studies Large-scale human studies have consistently demonstrated robust associations between EED exposure and deterioration in fundamental reproductive parameters, including sperm concentration, motility, and DNA integrity