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Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes

Interestingly, single alanine amino acid substitutions of some interacting residues within the TMD had much larger effects on exendin-4 affinity than removal of the first 8 residues of the peptide, suggesting that peptide ECD and TMD interactions are correlated, such that non-optimal interactions with the TMD likely promote faster peptide dissociation from the ECD

some indicate that its not the drug but rather the rapid improvement in glycemic control that may affect eye disease

Pareek A et al

Elevated intracellular calcium and possible PKC activation may collectively impact gene transcription events, presumably supporting growth hormone synthesis and secretion