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Briefly, cells were incubated in a serum-free Dulbeccos modified Eagles medium (DMEM) containing 10 M DCFH-DA at 37 C for 30 min

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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

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