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BPC-157 rapidly activates collateral blood vessels to bypass vascular obstructions, as demonstrated in colonic ischemia models where the peptide restored blood flow around ligated vessels within minutes to hours of administration

Up regulation of peripheral nitric oxide (NO), a vaso-relaxant

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Actions and Therapeutic Pathways of Ghrelin for Gastrointestinal Disorders

On one hand, increased cytochrome C release caused by mitochondrial calcium overload inhibits the negative feedback effect of cytoplasmic Ca 2+ on IP3 receptors, while on the other, it activates caspase3 to cleave IP3 receptors, hence forming a vicious cycle of massive calcium release from the ER[28]