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339 Additionally, PFKFB3-driven glycolysis also promotes histone Kla and boosts profibrotic gene expression in silica-treated mice, a process that can be inhibited by activating glucagon-like peptide-1 receptor (GLP-1R), disrupting the interaction between the NLRP3 inflammasome and PFKFB3, and intensifying pulmonary fibrosis progression

Data presented corresponds to five independent experiments performed in triplicate (N=5 for artemisinin, N=4 for chloroquine)

The specific L-NAMEinduced vascular failure points to normal intraocular pressure (except to very transitory increase upon drug retrobulbar administration)

[DOI] [PubMed] [Google Scholar] Dalle-Donne I, Rossi R, Giustarini D, Colombo R, Milzani A

Antioxidant Defense Glutathione acts as a powerful antioxidant, neutralizing free radicalsunstable molecules that can damage cells