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By emphasizing mechanistic insights, this review aims to inform the optimization of personalized weight-loss strategies and guide the development of non-surgical interventions that mimic the metabolic benefits of bariatric surgery [5]

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Chronic elevation of cortisol, leads to glutamate accumulation, excitotoxicity, and oxidative damage, underscoring its dual role in maintaining homeostasis and contributing to pathology

Acknowledgements We gratefully acknowledge the valuable cooperation of Huiping Ma (Center of Animal Experiment, Chinese Peoples Liberation Army Joint Logistic Support Force 940th Hospital) in preparing this animal model experiment