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Integrating ChIP-seq, HiC, and PRO-seq datasets, we revealed broad functional binding of NRF2 at enhancer elements, including NRF2-dependent enhancer-derived RNA (eRNA) synthesis and extensive linkages between NRF2 target promoters and enhancers

In liver cancer, NAPRT expression reflects the ability of the organ to synthesize NAD + 334 , thus highlighting the importance of tissue gene expression to be considered when targeting a particular organ

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