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In recent decades, berberine has gained attention in Western countries as a dietary supplement marketed for metabolic health, particularly for blood glucose management and lipid control

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Crow's feet from smiling, forehead lines from raising eyebrows, and "eleven" lines between the brows from frowning all fall into this category

D57 (CTR) and D254 (G), were predicted protonated, however, visual inspection did not support this prediction because of their solvent-exposed location and, therefore, were modelled in the anionic side chain form

The ECM is vital in facilitating tumor transformation, protecting tumors from immune surveillance, and aiding their growth and invasion