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Malnourishment, eating disorders, and cachexia (muscle wasting) can also increase the risk of liver injury following overdose (Ferner 2011)

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Sun CL, Hanig JP (1983): Alteration of sensitivity of adrenergic vascular responses after prolonged exposure to agonists via osmotic minipump

The above figure emphasizes another aspect of the proposed studies, the relationship between S and N excretion