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What We Know: Safety Data Through 80104 Weeks Status as of June 2026: The longest published retatrutide data now comes from TRIUMPH-1 at 80 weeks (with a 104-week extension for the BMI 35 subgroup)

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GLP-1 receptor agonists are commonly associated with gastrointestinal adverse events, which may lead to dehydration in some people [112]

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Second, because this retrospective analysis relies on de-identified, aggregated data from the TriNetX Research Network, under-reporting or misclassification of herpes infections and the inability to validate comorbidities with 2 ICD-coded encounters on separate dates may introduce misclassification bias