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Johns Wort, ginseng, and turmeric , can induce or inhibit cytochrome P450 enzymes, particularly CYP3A4 , leading to unpredictable changes in systemic drug levels

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Currently, the use of rational in vivo animal models and in vitro experimental assays is important in evaluating the effects of bioactive peptide use (99), however, it is difficult to take into account bioavailability-related factors such as gastrointestinal digestibility and peptide utilisation for the assessment of learning memory capacity using neuronal cells alone

In one embodiment the buffer is a sodium citrate buffer having a pH of about 6.0 to about 6.5

In: Encyclopedic Reference of Molecular Pharmacology