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These vision loss claims remain separate from the federal multidistrict litigation (MDL 3094) involving gastrointestinal injuries allegedly caused by GLP-1 drugs, which is currently centralized in the Eastern District of Pennsylvania and includes over 1,900 cases

Case presentation A 58-year-old female presented to our emergency department in a wheelchair with severe pitting edema and pain in both lower extremities as well as oliguria after a suicidal attempt that she took vildagliptin 1,400 mg (14-times the normal dosage)

Not the top of the stopper

While there are no randomized trials specifically testing probiotics for retatrutide-related diarrhea, the mechanistic rationale is strong

Consistent with the data in Glp1r -deficient islets, GLP-1(7-36) when used at picomolar concentrations retained an inhibitory effect in the presence of exendin(9-39)