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In some cases, vacuolar peptidases may cleave the glutamate and glycine of the original glutathione molecule, leaving the cysteinyl conjugate (cysteine-X) which may need further processing in Phase III reactions, such as incorporation into cell wall material

While pills are often destroyed by the digestive system, liposomal formulas use a phospholipid bilayer to protect the glutathione and deliver it directly to the cells.

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Conclusion: Topical glutathione shows promise for dermatological applications