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This includes individuals with a personal or family history of medullary thyroid carcinoma, those with Multiple Endocrine Neoplasia syndrome type 2, patients with type 1 diabetes or diabetic ketoacidosis, anyone currently taking another GLP-1 receptor agonist medication, pregnant or breastfeeding individuals, and patients with active pancreatitis

And so when we look at that what we basically can say is that when you do something to an exponential extent, right from 2 to 5 minutes to 24 hours, seven days a week, you are going to see an exacerbation of any underlying issues