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Knottnerus SJG, Bleeker JC, Wst RCI, Ferdinandusse S, IJlst L, Wijburg FA, et al

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Representative designs include pH-responsive carriers, redox-sensitive disulfide systems, protease-responsive carriers activated by enzymes such as MMP-2 or MMP-9, and hypoxia-responsive systems based on oxygen-sensitive linkers, prodrugs or oxygen-modulating components [46, 47, 49, 84, 100]

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