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Add in the GLP-1 wave, and suddenly everyones paying attention to sugar, so-called ultra-processed carbohydrates, hidden calories, and anything that spikes insulin

There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014

The withdrawal experience from semaglutide provides instructive context

Walker, Racz, and McElligott 1985)

These could indicate a more serious allergic reaction that requires immediate medical attention