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Brown JS, Amend SR, Austin RH, Gatenby RA, Hammarlund EU, Pienta KJ

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Originally developed through groundbreaking research at Erasmus University Medical Center, FOXO4-DRI represents a targeted approach to cellular rejuvenation and has shown remarkable promise in preclinical studies for promoting healthspan and addressing age-related cellular dysfunction

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To uncover the underlying mechanisms, the researchers analyzed hippocampal tissue focusing on dentate gyrus, where they quantified neural progenitor proliferation and neurogenesis through BrdU, immunofluorescence for Sox2, GFAP, DCX and NeuN, and unbiased stereological cell counting