Patients who experience substantial weight loss or excellent glycemic control with minimal side effects are more likely to continue long-term therapy
As a synthetic GLP-1 analog sharing approximately 94% sequence homology with native human GLP-1, semaglutide retains the biological activity of the endogenous hormone while incorporating structural modifications that enhance resistance to enzymatic degradation and prolong systemic exposure [2]
However, if you experience severe pain, swelling that spreads beyond the injection site, signs of infection (warmth, pus, fever), or pain that worsens over days instead of improving, contact your prescriber
Read more here Real World Perspectives on Long Term Use Discussions about GLP-1s in online communities and patient groups reveal a growing acceptance of these medications as ongoing treatment rather than short term interventions
Wegovy may still provide metabolic benefits and appetite regulation even during corticosteroid therapy, and weight loss typically improves once the prednisolone course is completed
