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This portfolio spans from the foundational disease model ( Uox KO mice ) to fully humanized models targeting uric acid production ( XDH ), uric acid excretion ( URAT1 ), and the gouty inflammatory cascade ( NLRP3 , IL1B )
Schadendorf D, van Akkooi A C, Berking C et al
Full effects may take 8 weeks or longer
If additional glycemic control is needed after at least 30 days on the 7 mg dose, escalation to 14 mg once daily may be considered
In neurological diseases, functional defects in N-methyl-D-aspartate receptors (NMDARs) are the major defects that cause neural signaling disorders
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