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Could a daily tablet replace weight loss injections like Wegovy and Mounjaro

L cells express the surface receptor TGR5, and TGR5 agonists such as 6-ethyl-23(S)-methylcholic acid (EMCA, INT-777) can induce GLP-1 release, modulating insulin secretion and delaying gastric emptying

Szegezdi, J., et al

in retatrutide, this effect is thought to be offset by the concurrent GLP-1 and GIP receptor agonism, which promote insulin secretion

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