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A separate meta-analysis by Maisel and colleagues from 2017 reached similar conclusions, reinforcing naltrexones role as one of the best-studied medications for reducing alcohol consumption

High-performance Liquid Chromatography Analysis A LaChrom ELITE system (Hitachi High-Tech Corporation, Tokyo, Japan) was used for the high-performance liquid chromatography (HPLC) analysis, with a L2100 pump, L2200 autosampler, L2300 column oven, and L2455 detector

Low sperm count, clinically known as oligospermia, means a semen sample contains fewer than 16 million sperm per millilitre, the lower reference limit set by the World Health Organization's 6th edition laboratory manual (2021)