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7 Glutathione-mediated regulation of NF-B, MAPK, and PI3K/AKT pathways in cancer progression and metastasis The NF-B, MAPK, and PI3K/AKT pathways are key regulators of tumor growth, resistance to oxidative stress, and metastasis, operating through redox-sensitive signaling mechanisms

Therefore, it is suggested that the mutation of Asp240 (into Thr240 and Lys240) leads to the disturbance of the above described hydrogen-network, which ultimately affects the enzymes activity

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This finding is also consistent with one MRS and one post-mortem study that showed higher GSH levels in frontal cortices in older adults (Hupfeld et al., 2021