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Even 20-30 minutes of low-intensity cardio (walking, cycling, swimming) makes a noticeable difference

Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]

Not only do patients lose significantly more weight with bariatric surgery than with conventional measures, but surgery also reduces and often cures conditions associated with obesity

Liraglutide also demonstrated histologic improvement in the LEAN trial with 39% NASH resolution

However, its a hypothesis