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MedLine Plus and other sources report that some of the side effects may be severe

By inhibiting NNMT, the body maintains higher NAD levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance

In preclinical mouse models, this produced significant reductions in body weight and fat mass without changes in food intake

J.P.H.W

Cardiovascular side effects, while less common, may include changes in heart rate, with some patients experiencing a mild increase in resting heart rate of two to three beats per minute on average