semaglutide injection how it works Mechanism of Action Tirzepatide vs Semaglutide: Which Weight

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The two major incretins are GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

The evidence base behind semaglutide Semaglutide's weight-management data come chiefly from the STEP trial program, published in The New England Journal of Medicine in 2021

Beyond GLP-1 and GIP receptors, it also activates Glucagon receptors

Follow-up testing also showed healthier IGF-1 levels, confirming the body was responding as expected