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These actions collectively contribute to improved glucose control and significant weight reduction

Cell uptake assays demonstrated that P478L impaired carnitine uptake, did not change Na + activation kinetics and enhanced TEA uptake 16 , altogether supporting a link between TM11 flexibility and carnitine binding

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In contrast, cAMP signaling in response to GLP-1 was comparable between wild-type and mutant receptors, supporting the hypothesis that altered signaling with PF-06882961 was not due to a marked alteration of surface expression for the mutated constructs (Fig

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