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Lourenco, M

as excess energy accumulates, white adipose tissue (WAT) cells undergo abnormal, hypertrophic growth, leading to poor blood supply (hypoxia), macrophage infiltration, and systemic inflammation

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In this context, low energy availability (LEA) represents a well-characterized physiological state in which insufficient caloric intake relative to exercise and basal demands induces coordinated endocrine and metabolic adaptations [88]

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