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On the other hand, GGCT overexpression enhances the metabolic flux of Glc into TCA cycle, providing sufficient energy and critical metabolic intermediates required for rapid cell proliferation

Amartely, H., Iosub-Amir, A

Furthermore, inhibition of phosphofructokinase-1 would lead to a buildup of fructose-6-phosphate, leading to a buildup of glucose-6-phosphate through phosphoglucose isomerase, which would be diverted to the pentose phosphate pathway, as it has been demonstrated 193,194

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Ren X, Li Y, Zhou Y, Hu W, Yang C, Jing Q, Zhou C, Wang X, Hu J, Wang L, et al